Thomas Jefferson Withers (1804 – November 7, 1865) was a Confederate politician from South Carolina who served in the Confederate States Congress during the American Civil War.
Withers was born in York County, South Carolina, and served as a state court judge in 1846. He represented the state in the Provisional Confederate Congress in 1861 and signed the Confederate States Constitution.
Withers died at Camden in Kershaw County, South Carolina and was interred at the Quaker Cemetery in the same city.